Postdoctoral Associate- Human Genetics

Summary

Dr. Ryan Dhindsa’s lab is seeking a Postdoctoral Associate to work on an NIH-funded project. The Dhindsa Lab integrates human genomics, single-cell multi-omics, and stem cell models to advance precision medicine. We place a particular emphasis on understanding mechanisms of neurodevelopmental disorders and other brain illnesses to identify more effective and targeted therapies. We apply cutting-edge technologies in our research and are dedicated to mentoring the next generation of scientists.

The postdoctoral fellow will lead innovative research projects focused on studying the molecular convergence of neurodevelopmental disease, including autism, intellectual disability, and epilepsy.  Almost 30% of genes implicated in neurodevelopmental disease encode transcriptional regulators including chromatin modifiers, transcription factors, and RNA-binding proteins. It is likely that many of these genes converge on shared downstream pathways, the identification of which could dramatically accelerate drug discovery. To identify these pathways, the postdoctoral fellow will use human iPSC-derived neurons and cutting-edge approaches, including single-cell RNA-sequencing (perturb-seq), chromatin profiling, and electrophysiology assays.

Job Duties

• 
  Plans and conducts experiments, analyzes data, and prepares publications describing results.
  


• 
  Helps in training and mentoring of lab personnel, including graduate and undergraduate students.
  


• 
  Maintains good communication with lab leader and members.
  


• 
  Reads and evaluates literature
  

Minimum Qualifications

• 
  MD or Ph.D. in Basic Science, Health Science, or a related field.
  


• 
  No experience required.
  

Preferred Qualifications

• 
  PhD in genomics, neuroscience, or related field.
  


• 
  Single-cell RNA-sequencing experience
  


• 
  Experience with stem cell culture, flow cytometry, microscopy, and electrophysiology
  


• 
  Experience with R or Python